the furthest I've driven my V in one shot is just shy of 250 miles, so not as far as you, but i can say that once on the highway with the cruise control set it was perfectly fine. I know there are other members who have done long trips, so maybe they can chime in here. I'll be driving my versa to ohio this summer though, a 15 hour trip! I suspect that i will have no issues wth it however.