I've never had P0300 come up on any of my vehicles but hopefully this will send you in new directions. Nissan Versa P0300: Engine Misfire Detected | Drivetrain Resource I know some models of the Versa had fuel regulator issues. If that's not the problem I'd try testing the cam/crank sensors and check the EGR system is operating properly. I would think that a cam/crank sensor and probably EGR problems would set other codes as well.